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mccB [2017-8-11 16:0:3]
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mccB [2017-8-11 16:0:3]

cystathionine lyase/ homocysteine gamma-lyase
Locus
BSU27250
Isoelectric point
5.22
Molecular weight
40.73 kDa
Protein length
379 aa Sequence Blast
Gene length
1137 bp Sequence Blast
Function
methionine-to-cysteine conversion
Product
cystathionine lyase/ homocysteine gamma-lyase
Essential
no
E.C.
4.4.1.1
Synonyms
yrhB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of cysteine

    • Gene

    Coordinates
    2,785,001 → 2,786,140

    The protein

    Catalyzed reaction/ biological activity

  • L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (according to Swiss-Prot)

    • Protein family

  • trans-sulfuration enzymes family (according to Swiss-Prot)

    • Structure

  • 4L0O (from Helicobacter pylori, 61% identity)

    • Localization

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    yrrT-mtnN-mccA-mccB-yrhC
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

    • Regulatory mechanism

  • CymR: repression, PubMed, in CymR regulon
  • Spx: activation, PubMed, in Spx regulon

    • Regulation

  • repressed in the presence of cysteine (CymR) PubMed
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    Biological materials

    Mutant

  • MGNA-A848 (yrhB::erm), available at the NBRP B. subtilis, Japan
  • 1A942 ( mccB::kan), PubMed, available at BGSC
  • 1A945 ( mccB::kan), PubMed, available at BGSC

    • References

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